Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer.

O'Brien, Shane; Butticello, Michael; Thompson, Christine; Wilson, Boris; Wyce, Anastasia; Mahajan, Vivek; Kruger, Ryan; Mohammad, Helai; Fedoriw, Andy

O'Brien, Shane; Butticello, Michael; Thompson, Christine; Wilson, Boris; Wyce, Anastasia; Mahajan, Vivek; Kruger, Ryan; Mohammad, Helai; Fedoriw, Andy.

Afiliação

O'Brien S; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA.
Butticello M; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA.
Thompson C; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA.
Wilson B; Synthetic Lethality RU, GlaxoSmithKline, Collegeville, USA.
Wyce A; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA.
Mahajan V; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA.
Kruger R; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA.
Mohammad H; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA.
Fedoriw A; Tumor Cell Targeting RU, GlaxoSmithKline, Collegeville, USA. andy.x.fedoriw@gsk.com.

BMC Cancer ; 23(1): 775, 2023 Aug 18.

Article em En | MEDLINE | ID: mdl-37596538

Assuntos

Antineoplásicos; Neoplasias Ovarianas; Humanos; Feminino; Animais; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Inibidores de Poli(ADP-Ribose) Polimerases/uso terapêutico; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Neoplasias Ovarianas/tratamento farmacológico; Dano ao DNA; Modelos Animais de Doenças; Proteína-Arginina N-Metiltransferases

Palavras-chave

Breast; Combinations; Ovarian; PARP; Protein methyltransferase 5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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