Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults.
Clin Exp Immunol
; 214(1): 79-93, 2023 12 11.
Article
em En
| MEDLINE
| ID: mdl-37605554
ABSTRACT
Respiratory syncytial virus (RSV) infections are a major cause of bronchiolitis and pneumonia in infants and older adults, for which there is no known correlate of protection. Increasing evidence suggests that Fc-mediated antibody effector functions have an important role, but little is known about the development, heterogeneity, and durability of these functional responses. In light of future vaccine strategies, a clear view of the immunological background and differences between various target populations is of crucial importance. In this study, we have assessed both quantitative and qualitative aspects of RSV-specific serum antibodies, including IgG/IgA levels, IgG subclasses, antibody-dependent complement deposition, cellular phagocytosis, and NK cell activation (ADNKA). Samples were collected cross-sectionally in different age groups (11-, 24-, and 46-month-old children, adults, and older adults; nâ
=â
31-35 per group) and longitudinally following natural RSV infection in (older) adults (2-36 months post-infection; nâ
=â
10). We found that serum of 24-month-old children induces significantly lower ADNKA than the serum of adults (Pâ
<â
0.01), which is not explained by antibody levels. Furthermore, in (older) adults we observed boosting of antibody levels and functionality at 2-3 months after RSV infection, except for ADNKA. The strongest decrease was subsequently observed within the first 9 months, after which levels remained relatively stable up to three years post-infection. Together, these data provide a comprehensive overview of the functional landscape of RSV-specific serum antibodies in the human population, highlighting that while antibodies reach adult levels already at a young age, ADNKA requires more time to fully develop.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus Sincicial Respiratório Humano
/
Infecções por Vírus Respiratório Sincicial
Tipo de estudo:
Qualitative_research
Limite:
Aged
/
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article