The effects of Digoxin use on long-term prognosis in patients with heart failure with reduced ejection fraction.
Eur Rev Med Pharmacol Sci
; 27(15): 7226-7234, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37606130
ABSTRACT
OBJECTIVE:
This study aimed to investigate the effect of digoxin on mortality and rehospitalization in heart failure with reduced ejection fraction (HFrEF) patients. Heart failure is a clinical syndrome that requires frequent rehospitalization and has a high mortality. This study aimed to investigate the effect of digoxin on mortality and rehospitalization in patients with heart failure with reduced ejection fraction. PATIENTS ANDMETHODS:
The study included 326 patients with HFrEF that were hospitalized for decompensation between September 2014 and January 2016. The patients were divided into two groups digoxin users and a control group. The study's endpoints were cardiovascular death and rehospitalization after 24-month long-term follow-ups.RESULTS:
Rehospitalization was lower in patients taking digoxin (25% vs. 47%, p = 0.001). The mean age of patients taking digoxin (n 78) was 63.7 ± 12.4 years, among which 64% were males. The mean age of the control group was 65.4 ± 11.8 years, among which 74% were males. However, there was no difference in mortality between the two groups (34% vs. 45%, p = 0.10). While Kaplan-Meier curves revealed no significant differences between mortality rates in the groups (log-rank p = 0.508), a statistical difference was found between the groups in rehospitalization rates (log-rank p = 0.013). A multiple linear regression analysis revealed that smoking (HR 1.97, CI 1.24-3.11, p = 0.004), systolic blood pressure (HR 0.983, CI 0.974-0.992, p < 0.001), atrial fibrillation (HR 2.09, CI 1.17-3.72, p = 0.012), C-reactive protein (CRP) (HR 1.009, CI 1.003-1.015, p = 0.004), beta-blockers (HR 0.891, CI 0.799-0.972, p = 0.009), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (HR 0.778, CI 0.641-0.956, p < 0.001), mineralocorticoid receptor antagonists (HR 0.41, CI0.26-0.65, p < 0.001), and digoxin use (HR 0.59, CI 0.43-0.80, p = 0.001) are independent predictors of rehospitalization in patients with HFrEF.CONCLUSIONS:
Our results show that digoxin use does not affect mortality in HFrEF patients. However, rehospitalization decreased in patients taking digoxin in HFrEF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
/
Insuficiência Cardíaca
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article