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An antibiotic from an uncultured bacterium binds to an immutable target.
Shukla, Rhythm; Peoples, Aaron J; Ludwig, Kevin C; Maity, Sourav; Derks, Maik G N; De Benedetti, Stefania; Krueger, Annika M; Vermeulen, Bram J A; Harbig, Theresa; Lavore, Francesca; Kumar, Raj; Honorato, Rodrigo V; Grein, Fabian; Nieselt, Kay; Liu, Yangping; Bonvin, Alexandre M J J; Baldus, Marc; Kubitscheck, Ulrich; Breukink, Eefjan; Achorn, Catherine; Nitti, Anthony; Schwalen, Christopher J; Spoering, Amy L; Ling, Losee Lucy; Hughes, Dallas; Lelli, Moreno; Roos, Wouter H; Lewis, Kim; Schneider, Tanja; Weingarth, Markus.
Afiliação
  • Shukla R; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Peoples AJ; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA.
  • Ludwig KC; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Maity S; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands.
  • Derks MGN; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • De Benedetti S; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Krueger AM; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands.
  • Vermeulen BJA; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Harbig T; Integrative Transcriptomics, Center for Bioinformatics, University of Tübingen, 72070 Tübingen, Germany.
  • Lavore F; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Kumar R; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Honorato RV; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Grein F; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany.
  • Nieselt K; Integrative Transcriptomics, Center for Bioinformatics, University of Tübingen, 72070 Tübingen, Germany.
  • Liu Y; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
  • Bonvin AMJJ; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Baldus M; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Kubitscheck U; Clausius-Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany.
  • Breukink E; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
  • Achorn C; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA.
  • Nitti A; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA.
  • Schwalen CJ; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Spoering AL; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA.
  • Ling LL; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA.
  • Hughes D; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA.
  • Lelli M; Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 3, Sesto Fiorentino 50019, Italy; Consorzio Interuniversitario Risonanze Magnetiche MetalloProteine (CIRMMP), via Sacconi 6, Sesto Fiorentino 50019, Italy.
  • Roos WH; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands.
  • Lewis K; Antimicrobial Discovery Center, Northeastern University, Department of Biology, Boston, MA 02115, USA.
  • Schneider T; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany. Electronic address: tschneider@uni-bonn.de.
  • Weingarth M; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands. Electronic address: m.h.weingarth@uu.nl.
Cell ; 186(19): 4059-4073.e27, 2023 09 14.
Article em En | MEDLINE | ID: mdl-37611581
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbiologia do Solo / Bactérias / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbiologia do Solo / Bactérias / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article