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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5.
Diegel, Cassandra R; Kramer, Ina; Moes, Charles; Foxa, Gabrielle E; McDonald, Mitchell J; Madaj, Zachary B; Guth, Sabine; Liu, Jun; Harris, Jennifer L; Kneissel, Michaela; Williams, Bart O.
Afiliação
  • Diegel CR; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA.
  • Kramer I; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland.
  • Moes C; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland.
  • Foxa GE; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA.
  • McDonald MJ; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA.
  • Madaj ZB; Bioinformatics and Biostatistics Core, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA.
  • Guth S; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland.
  • Liu J; Oncology, Novartis Institutes for Biomedical Research, San Diego, CA, 92121, USA.
  • Harris JL; Oncology, Novartis Institutes for Biomedical Research, San Diego, CA, 92121, USA.
  • Kneissel M; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland.
  • Williams BO; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA. bart.williams@vai.org.
Bone Res ; 11(1): 47, 2023 08 24.
Article em En | MEDLINE | ID: mdl-37612291
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperostose / Mutação com Ganho de Função Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperostose / Mutação com Ganho de Função Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article