Genetic inactivation of ß-catenin is salubrious, whereas its activation is deleterious in desmoplakin cardiomyopathy.

Olcum, Melis; Fan, Siyang; Rouhi, Leila; Cheedipudi, Sirisha; Cathcart, Benjamin; Jeong, Hyun-Hwan; Zhao, Zhongming; Gurha, Priyatansh; Marian, Ali J

Olcum, Melis; Fan, Siyang; Rouhi, Leila; Cheedipudi, Sirisha; Cathcart, Benjamin; Jeong, Hyun-Hwan; Zhao, Zhongming; Gurha, Priyatansh; Marian, Ali J.

Afiliação

Olcum M; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Fan S; The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Rouhi L; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Cheedipudi S; The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Cathcart B; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Jeong HH; The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Zhao Z; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Gurha P; The Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Marian AJ; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.

Cardiovasc Res ; 119(17): 2712-2728, 2023 12 30.

Article em En | MEDLINE | ID: mdl-37625794

Assuntos

Displasia Arritmogênica Ventricular Direita; Cardiomiopatias; Camundongos; Animais; Displasia Arritmogênica Ventricular Direita/genética; Desmoplaquinas/genética; Desmoplaquinas/metabolismo; beta Catenina/genética; beta Catenina/metabolismo; Cardiomiopatias/genética; Arritmias Cardíacas/metabolismo; Fibrose

Palavras-chave

Cardiomyopathy; Cell death; Desmoplakin; Fibrosis; Oxidative phosphorylation; WNT pathway; ß-Catenin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Displasia Arritmogênica Ventricular Direita / Cardiomiopatias Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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