Mechanoregulatory Cholesterol Oxidase-Functionalized Nanoscale Metal-Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells.

Zhen, Wenyao; Luo, Taokun; Wang, Zitong; Jiang, Xiaomin; Yuan, Eric; Weichselbaum, Ralph R; Lin, Wenbin

Zhen, Wenyao; Luo, Taokun; Wang, Zitong; Jiang, Xiaomin; Yuan, Eric; Weichselbaum, Ralph R; Lin, Wenbin.

Afiliação

Zhen W; Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Luo T; Department of Radiation and Cellular Oncology, The Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, 60637, USA.
Wang Z; Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Jiang X; Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Yuan E; Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Weichselbaum RR; Department of Radiation and Cellular Oncology, The Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, 60637, USA.
Lin W; Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.

Small ; 19(52): e2305440, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37635106

Assuntos

Estruturas Metalorgânicas; Neoplasias; Humanos; Estruturas Metalorgânicas/farmacologia; Colesterol Oxidase; Piroptose; Linfócitos T; Colesterol; Microambiente Tumoral

Palavras-chave

cholesterol depletion; immune checkpoints; nanoscale metal-organic frameworks; pyroptosis; tumor microenvironment remodeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estruturas Metalorgânicas / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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