Perturbation of the insomnia <i>WDR90</i> GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, <i>PIG-Q</i>.

Sonti, Shilpa; Littleton, Sheridan H; Pahl, Matthew C; Zimmerman, Amber J; Chesi, Alessandra; Palermo, Justin; Lasconi, Chiara; Brown, Elizabeth B; Pippin, James A; Wells, Andrew D; Doldur-Balli, Fusun; Pack, Allan I; Gehrman, Phillip R; Keene, Alex C; Grant, S F A

Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.

Sonti, Shilpa; Littleton, Sheridan H; Pahl, Matthew C; Zimmerman, Amber J; Chesi, Alessandra; Palermo, Justin; Lasconi, Chiara; Brown, Elizabeth B; Pippin, James A; Wells, Andrew D; Doldur-Balli, Fusun; Pack, Allan I; Gehrman, Phillip R; Keene, Alex C; Grant, S F A.

Afiliação

Sonti S; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Littleton SH; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Pahl MC; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zimmerman AJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Chesi A; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Palermo J; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Lasconi C; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Brown EB; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Pippin JA; Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA.
Wells AD; Department of Biology, Texas A&M University, College Station, TX, USA.
Doldur-Balli F; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Pack AI; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Gehrman PR; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Keene AC; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Grant SFA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

bioRxiv ; 2023 Aug 18.

Article em En | MEDLINE | ID: mdl-37645863

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article