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Small conformational changes in IgG1 detected as acidic charge variants by cation exchange chromatography.
Fukuda, Masakazu; Graewert, Melissa A; Jeffries, Cy M; Svergun, Dmitri I; Yamazaki, Tadao; Koga, Akiko; Yamanaka, Yuji.
Afiliação
  • Fukuda M; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, 115-8543, Japan; Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan. Electronic address: fukudamk@kobepharma-
  • Graewert MA; European Molecular Biology Laboratory (EMBL) Hamburg Unit, c/o Deutsches Elektronen Synchrotron (DESY), 22607, Hamburg, Germany.
  • Jeffries CM; European Molecular Biology Laboratory (EMBL) Hamburg Unit, c/o Deutsches Elektronen Synchrotron (DESY), 22607, Hamburg, Germany.
  • Svergun DI; European Molecular Biology Laboratory (EMBL) Hamburg Unit, c/o Deutsches Elektronen Synchrotron (DESY), 22607, Hamburg, Germany.
  • Yamazaki T; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, 115-8543, Japan.
  • Koga A; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, 115-8543, Japan.
  • Yamanaka Y; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, 115-8543, Japan.
Anal Biochem ; 680: 115302, 2023 11 01.
Article em En | MEDLINE | ID: mdl-37652129
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Anticorpos Monoclonais Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Anticorpos Monoclonais Idioma: En Ano de publicação: 2023 Tipo de documento: Article