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BRAFΔß3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability.
Lauinger, Manuel; Christen, Daniel; Klar, Rhena F U; Roubaty, Carole; Heilig, Christoph E; Stumpe, Michael; Knox, Jennifer J; Radulovich, Nikolina; Tamblyn, Laura; Xie, Irene Y; Horak, Peter; Forschner, Andrea; Bitzer, Michael; Wittel, Uwe A; Boerries, Melanie; Ball, Claudia R; Heining, Christoph; Glimm, Hanno; Fröhlich, Martina; Hübschmann, Daniel; Gallinger, Steven; Fritsch, Ralph; Fröhling, Stefan; O'Kane, Grainne M; Dengjel, Jörn; Brummer, Tilman.
Afiliação
  • Lauinger M; Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
  • Christen D; Faculty of Biology, University of Freiburg, Freiburg, Germany.
  • Klar RFU; Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
  • Roubaty C; Faculty of Biology, University of Freiburg, Freiburg, Germany.
  • Heilig CE; German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Stumpe M; Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
  • Knox JJ; Faculty of Biology, University of Freiburg, Freiburg, Germany.
  • Radulovich N; German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Tamblyn L; Freeze-O Organoid Bank, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Xie IY; Department of Internal Medicine I (Hematology, Oncology, and Stem Cell Transplantation), University Hospital of Freiburg, Freiburg, Germany.
  • Horak P; Institute of Medical Bioinformatics and Systems Medicine (IBSM), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Forschner A; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
  • Bitzer M; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Wittel UA; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Boerries M; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
  • Ball CR; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Heining C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Glimm H; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Fröhlich M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Hübschmann D; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Gallinger S; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Fritsch R; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Fröhling S; Department of Dermatology, University Hospital of Tübingen, Tübingen, Germany.
  • O'Kane GM; German Cancer Consortium (DKTK), DKFZ partner site Tübingen, Eberhard Karls University, Tübingen, Germany.
  • Dengjel J; German Cancer Consortium (DKTK), DKFZ partner site Tübingen, Eberhard Karls University, Tübingen, Germany.
  • Brummer T; Center for Personalized Medicine Tübingen, Eberhard Karls University, Tübingen, Germany.
Sci Adv ; 9(35): eade7486, 2023 09.
Article em En | MEDLINE | ID: mdl-37656784

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP90 / Proteínas Proto-Oncogênicas B-raf Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP90 / Proteínas Proto-Oncogênicas B-raf Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article