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Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors.
Narlawar, Rajeshwar; Serneels, Lutgarde; Gaffric, Celia; Gijsen, Harrie J M; De Strooper, Bart; Bischoff, François.
Afiliação
  • Narlawar R; Discovery Chemistry, Therapeutics Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340, Beerse, Belgium; KU Leuven, Department of Neurosciences, Leuven Institute for Neuroscience and Disease, (LIND), Leuven, Belgium. Electronic address: rajnarlawar@gmail.
  • Serneels L; VIB Center for Brain and Disease Research, Leuven, Belgium.
  • Gaffric C; Discovery Chemistry, Therapeutics Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340, Beerse, Belgium.
  • Gijsen HJM; Discovery Chemistry, Therapeutics Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340, Beerse, Belgium.
  • De Strooper B; KU Leuven, Department of Neurosciences, Leuven Institute for Neuroscience and Disease, (LIND), Leuven, Belgium; VIB Center for Brain and Disease Research, Leuven, Belgium; Dementia Research Institute, University College London, London, UK.
  • Bischoff F; Discovery Chemistry, Therapeutics Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340, Beerse, Belgium. Electronic address: francoisbischoff@yahoo.fr.
Eur J Med Chem ; 260: 115725, 2023 Nov 15.
Article em En | MEDLINE | ID: mdl-37657269
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Secretases da Proteína Precursora do Amiloide Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Secretases da Proteína Precursora do Amiloide Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article