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Biomarkers of aging for the identification and evaluation of longevity interventions.
Moqri, Mahdi; Herzog, Chiara; Poganik, Jesse R; Justice, Jamie; Belsky, Daniel W; Higgins-Chen, Albert; Moskalev, Alexey; Fuellen, Georg; Cohen, Alan A; Bautmans, Ivan; Widschwendter, Martin; Ding, Jingzhong; Fleming, Alexander; Mannick, Joan; Han, Jing-Dong Jackie; Zhavoronkov, Alex; Barzilai, Nir; Kaeberlein, Matt; Cummings, Steven; Kennedy, Brian K; Ferrucci, Luigi; Horvath, Steve; Verdin, Eric; Maier, Andrea B; Snyder, Michael P; Sebastiano, Vittorio; Gladyshev, Vadim N.
Afiliação
  • Moqri M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA
  • Herzog C; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.
  • Poganik JR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Justice J; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Belsky DW; Department of Epidemiology, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Higgins-Chen A; Department of Psychiatry, Yale University, New Haven, CT, USA.
  • Moskalev A; Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia.
  • Fuellen G; Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany; School of Medicine, University College Dublin, Dublin, Ireland.
  • Cohen AA; Department of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Bautmans I; Gerontology Department, Vrije Universiteit Brussel, Brussels, Belgium; Frailty in Ageing Research Department, Vrije Universiteit Brussel, Brussels, Belgium.
  • Widschwendter M; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria; Department of Women's Cancer, EGA Institute for Women's Health, University College London, London, UK; Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, K
  • Ding J; Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Fleming A; Kitalys Institute, Charlottesville, VA, USA.
  • Mannick J; Tornado Therapeutics, New York, NY, USA.
  • Han JJ; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, China.
  • Zhavoronkov A; Insilico Medicine Hong Kong, Pak Shek Kok, New Territories, Hong Kong SAR, China.
  • Barzilai N; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Kaeberlein M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
  • Cummings S; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Kennedy BK; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ferrucci L; National Institute on Aging, Baltimore, MD, USA.
  • Horvath S; Altos Labs, San Diego, CA, USA.
  • Verdin E; Buck Institute for Research on Aging, Novato, CA, USA.
  • Maier AB; Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapo
  • Snyder MP; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: mpsnyder@stanford.edu.
  • Sebastiano V; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: vsebast@stanford.edu.
  • Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: vgladyshev@rics.bwh.harvard.edu.
Cell ; 186(18): 3758-3775, 2023 08 31.
Article em En | MEDLINE | ID: mdl-37657418
ABSTRACT
With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Longevidade Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Longevidade Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article