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Diabetes mellitus as a consequence of acute severe pancreatitis: Unraveling the mystery.
Manrai, Manish; Singh, Anupam K; Birda, Chhagan Lal; Shah, Jimil; Dutta, Aditya; Bhadada, Sanjay Kumar; Kochhar, Rakesh.
Afiliação
  • Manrai M; Department of Internal Medicine, Armed Forces Medical College, Pune 411040, Maharashtra, India.
  • Singh AK; Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • Birda CL; Department of Gastroenterology, All India Institutes of Medical Sciences, Jodhpur 342001, India.
  • Shah J; Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • Dutta A; Department of Endocrinology, Max Hospital, New Delhi 110017, India.
  • Bhadada SK; Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • Kochhar R; Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. dr_kochhar@hotmail.com.
World J Diabetes ; 14(8): 1212-1225, 2023 Aug 15.
Article em En | MEDLINE | ID: mdl-37664472
The occurrence of diabetes mellitus (DM) in pancreatitis is being increasingly recognized lately. Diabetes can develop not only with chronic pancreatitis but even after the first episode of acute pancreatitis (AP). The incidence of diabetes after AP varies from 18% to 23% in 3 years and reaches up to 40% over 5 years. The exact pathogenesis of diabetes after AP is poorly understood and various mechanisms proposed include loss of islet cell mass, AP-induced autoimmunity, and alterations in the insulin incretin axis. Risk factors associated with increased risk of diabetes includes male sex, recurrent attacks of pancreatitis, presence of pancreatic exocrine insufficiency and level of pancreatitic necrosis. Diagnosis of post-pancreatitis DM (PPDM) is often excluded. Treatment includes a trial of oral antidiabetic drugs in mild diabetes. Often, insulin is required in uncontrolled diabetes. Given the lack of awareness of this metabolic disorder after AP, this review will evaluate current information on epidemiology, risk factors, diagnosis and management of PPDM and identify the knowledge gaps.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article