Mutations in TAC1 and ERG11 are major drivers of triazole antifungal resistance in clinical isolates of Candida parapsilosis.

Doorley, Laura A; Barker, Katherine S; Zhang, Qing; Rybak, Jeffrey M; Rogers, P David

Doorley, Laura A; Barker, Katherine S; Zhang, Qing; Rybak, Jeffrey M; Rogers, P David.

Afiliação

Doorley LA; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Barker KS; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zhang Q; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Rybak JM; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Rogers PD; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: dave.rogers@stjude.org.

Clin Microbiol Infect ; 29(12): 1602.e1-1602.e7, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37666448

Assuntos

Antifúngicos; Fluconazol; Humanos; Antifúngicos/farmacologia; Fluconazol/farmacologia; Candida parapsilosis/genética; Triazóis/farmacologia; Proteínas Fúngicas/genética; Proteínas Fúngicas/metabolismo; Mutação; Farmacorresistência Fúngica/genética; Testes de Sensibilidade Microbiana

Palavras-chave

Candida parapsilosis; ERG11; Fluconazole; Resistance; TAC1; Triazole

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fluconazol / Antifúngicos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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