Bromodomain-containing protein 4 activates androgen receptor transcription and promotes ovarian fibrosis in PCOS.

Wang, Daojuan; Zhu, Zhengquan; Fu, Yu; Zhang, Qiong; Zhang, Yi; Wang, Tingyu; Weng, Yajing; Wen, Yanting; Cao, Wangsen; Tao, Gaojian; Wang, Yong

Wang, Daojuan; Zhu, Zhengquan; Fu, Yu; Zhang, Qiong; Zhang, Yi; Wang, Tingyu; Weng, Yajing; Wen, Yanting; Cao, Wangsen; Tao, Gaojian; Wang, Yong.

Afiliação

Wang D; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China; Department of Pain Management, Nanjing Drum Tower Hospital, Affiliated Hospital
Zhu Z; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China.
Fu Y; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China.
Zhang Q; Department of Obstetrics and Gynecology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Zhang Y; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China.
Wang T; Department of Pain Management, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Weng Y; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China.
Wen Y; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China.
Cao W; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China; Department of Nephrology, Yangzhou Precision Research Institute of Kidney Disea
Tao G; Department of Pain Management, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China. Electronic address: dreamout@njglyy.com.
Wang Y; The Affiliated Nanjing Drum Tower Hospital, and State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China. Electronic address: yongwang@nju.edu.cn.

Cell Rep ; 42(9): 113090, 2023 09 26.

Article em En | MEDLINE | ID: mdl-37669164

Assuntos

Síndrome do Ovário Policístico; Receptores Androgênicos; Animais; Feminino; Humanos; Ratos; Proteínas de Ciclo Celular; Fibrose; Proteínas Nucleares/genética; Síndrome do Ovário Policístico/genética; Síndrome do Ovário Policístico/metabolismo; Receptores Androgênicos/genética; Receptores Androgênicos/metabolismo; Fatores de Transcrição/genética

Palavras-chave

BRD4; CP: Cancer; CP: Metabolism; PCOS; androgen receptor; granulosa cell; ovarian fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Receptores Androgênicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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