Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction.

Guillien, Myriam; Mouhand, Assia; Sagar, Amin; Fournet, Aurélie; Allemand, Frédéric; Pereira, Glaécia A N; Thureau, Aurélien; Bernadó, Pau; Banères, Jean-Louis; Sibille, Nathalie

Guillien, Myriam; Mouhand, Assia; Sagar, Amin; Fournet, Aurélie; Allemand, Frédéric; Pereira, Glaécia A N; Thureau, Aurélien; Bernadó, Pau; Banères, Jean-Louis; Sibille, Nathalie.

Afiliação

Guillien M; Centre de Biologie Structurale (CBS), CNRS, University Montpellier, Inserm, Montpellier, France.
Mouhand A; Centre de Biologie Structurale (CBS), CNRS, University Montpellier, Inserm, Montpellier, France.
Sagar A; Centre de Biologie Structurale (CBS), CNRS, University Montpellier, Inserm, Montpellier, France.
Fournet A; Centre de Biologie Structurale (CBS), CNRS, University Montpellier, Inserm, Montpellier, France.
Allemand F; Centre de Biologie Structurale (CBS), CNRS, University Montpellier, Inserm, Montpellier, France.
Pereira GAN; Institut des Biomolécules Max Mousseron (IBMM), UMR-5247, University Montpellier, CNRS, ENSCM, Montpellier, France.
Thureau A; HélioBio Section, Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin BP 48, 91190 Gif-sur-Yvette, France.
Bernadó P; Centre de Biologie Structurale (CBS), CNRS, University Montpellier, Inserm, Montpellier, France.
Banères JL; Institut des Biomolécules Max Mousseron (IBMM), UMR-5247, University Montpellier, CNRS, ENSCM, Montpellier, France.
Sibille N; Centre de Biologie Structurale (CBS), CNRS, University Montpellier, Inserm, Montpellier, France. Electronic address: nathalie.sibille@cbs.cnrs.fr.

Structure ; 31(11): 1394-1406.e7, 2023 11 02.

Article em En | MEDLINE | ID: mdl-37669668

Assuntos

Arrestina; Receptores Acoplados a Proteínas G; Arrestina/química; Fosforilação; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Transdução de Sinais; Rodopsina/química

Palavras-chave

G protein-coupled receptor; GPCR; Intrinsically disordered regions; NMR; Nuclear Magnetic Resonance; Paramagnetic relaxation enhancement; Post-translational modifications; Protein-protein interaction; Residual Dipolar Couplings; arrestin; intrinsically disordered proteins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arrestina / Receptores Acoplados a Proteínas G Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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