T cell receptor gene-modified allogeneic T cells with siRNA for endogenous T cell receptor induce efficient tumor regression without graft-versus-host disease.

Okada, Satomi; Muraoka, Daisuke; Yasui, Kiyoshi; Tawara, Isao; Kawamura, Ayumi; Okamoto, Sachiko; Mineno, Junichi; Seo, Naohiro; Shiku, Hiroshi; Eguchi, Susumu; Ikeda, Hiroaki

Okada, Satomi; Muraoka, Daisuke; Yasui, Kiyoshi; Tawara, Isao; Kawamura, Ayumi; Okamoto, Sachiko; Mineno, Junichi; Seo, Naohiro; Shiku, Hiroshi; Eguchi, Susumu; Ikeda, Hiroaki.

Afiliação

Okada S; Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Muraoka D; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yasui K; Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Tawara I; Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Kawamura A; Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Okamoto S; Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan.
Mineno J; Takara Bio Inc., Shiga, Japan.
Seo N; Takara Bio Inc., Shiga, Japan.
Shiku H; Takara Bio Inc., Shiga, Japan.
Eguchi S; Department of Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Mie, Japan.
Ikeda H; Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.

Cancer Sci ; 114(11): 4172-4183, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37675556

Assuntos

Doença Enxerto-Hospedeiro; Transplante de Células-Tronco Hematopoéticas; Neoplasias; Camundongos; Animais; Humanos; RNA Interferente Pequeno/genética; Células Alógenas/metabolismo; Camundongos SCID; Receptores de Antígenos de Linfócitos T; Genes Codificadores dos Receptores de Linfócitos T; Imunoterapia Adotiva; Neoplasias/genética; Doença Enxerto-Hospedeiro/prevenção & controle

Palavras-chave

T cell receptor gene therapy; adoptive cell therapy; allogeneic cells; endogenous T cell receptor; human leukocyte antigen

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Doença Enxerto-Hospedeiro / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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