Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration.

Sekine, Yuichi; Wang, Xingxing; Kikkawa, Kazuna; Honda, Sachie; Strittmatter, Stephen M

Sekine, Yuichi; Wang, Xingxing; Kikkawa, Kazuna; Honda, Sachie; Strittmatter, Stephen M.

Afiliação

Sekine Y; Department of Neuroscience and Neurology, Cellular Neuroscience, Neurodegeneration & Repair Program, Yale School of Medicine, New Haven, Connecticut, USA; Department of Cell Biology, Kyoto Pharmaceutical University, Kyoto, Japan.
Wang X; Department of Neuroscience and Neurology, Cellular Neuroscience, Neurodegeneration & Repair Program, Yale School of Medicine, New Haven, Connecticut, USA.
Kikkawa K; Department of Cell Biology, Kyoto Pharmaceutical University, Kyoto, Japan.
Honda S; Department of Cell Biology, Kyoto Pharmaceutical University, Kyoto, Japan.
Strittmatter SM; Department of Neuroscience and Neurology, Cellular Neuroscience, Neurodegeneration & Repair Program, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address: stephen.strittmatter@yale.edu.

J Biol Chem ; 299(10): 105232, 2023 10.

Article em En | MEDLINE | ID: mdl-37690690

Assuntos

Axônios; Proteínas da Mielina; Animais; Camundongos; Axônios/metabolismo; Inibidores do Crescimento/metabolismo; Mamíferos/metabolismo; Proteínas da Mielina/genética; Proteínas da Mielina/metabolismo; Regeneração Nervosa/fisiologia; Proteínas Nogo/genética; Proteínas Nogo/metabolismo; Proteólise; Feminino; Camundongos Endogâmicos C57BL

Palavras-chave

axon; central nervous system (CNS); cerebral cortex; myelin; outgrowth inhibition; proteolysis; regeneration; spinal cord injury; trauma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Axônios / Proteínas da Mielina Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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