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Large-scale genomic survey and characterization of mcr genes carried by foodborne Cronobacter isolates.
Zhu, Qianhui; Hu, Jinrui; Liu, Na; Qi, Heyuan; Du, Xiaoli; Cui, Zhigang; Sun, Yan; Liu, Yadong; Hu, Songnian; Wu, Linhuan; Zhou, Haijian; He, Zilong; Ma, Juncai.
Afiliação
  • Zhu Q; School of Engineering Medicine, School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University , Beijing, Hebei, China.
  • Hu J; State Key Laboratory of Microbial Resources, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China.
  • Liu N; Institute of Microbiology, University of Chinese Academy of Sciences , Beijing, Hebei, China.
  • Qi H; State Key Laboratory of Infectious Disease Prevention and Control, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, Hebei, China.
  • Du X; School of Engineering Medicine, School of Engineering Medicine, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University , Beijing, Hebei, China.
  • Cui Z; State Key Laboratory of Microbial Resources, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China.
  • Sun Y; Microbial Resource and Big Data Center, Microbial Resource and Big Data Center, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China.
  • Liu Y; State Key Laboratory of Infectious Disease Prevention and Control, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, Hebei, China.
  • Hu S; State Key Laboratory of Infectious Disease Prevention and Control, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, Hebei, China.
  • Wu L; State Key Laboratory of Microbial Resources, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China.
  • Zhou H; Microbial Resource and Big Data Center, Microbial Resource and Big Data Center, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China.
  • He Z; State Key Laboratory of Microbial Resources, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China.
  • Ma J; Institute of Microbiology, University of Chinese Academy of Sciences , Beijing, Hebei, China.
mSystems ; 8(5): e0045023, 2023 Oct 26.
Article em En | MEDLINE | ID: mdl-37695127
IMPORTANCE: Cronobacter is an emerging foodborne opportunistic pathogen, which can cause neonatal meningitis, bacteremia, and NEC by contaminating food. However, the entire picture of foodborne Cronobacter carriage of the mcr genes is not known. Here, we investigated the mcr genes of Cronobacter isolates by whole-genome sequencing and found 133 previously undescribed Cronobacter isolates carrying mcr genes. Further genomic analysis revealed that these mcr genes mainly belonged to the mcr-9 and mcr-10. Genomic analysis of the flanking structures of mcr genes revealed that two core flanking structures were prevalent in foodborne Cronobacter isolates, and the flanking structure carrying IS1R was found for the first time in this study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cronobacter Tipo de estudo: Prognostic_studies Limite: Humans / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cronobacter Tipo de estudo: Prognostic_studies Limite: Humans / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article