Universal calcium fluctuations inHydramorphogenesis.
Phys Biol
; 20(6)2023 09 22.
Article
em En
| MEDLINE
| ID: mdl-37696269
Understanding the collective physical processes that drive robust morphological transitions in animal development necessitates the characterization of the relevant fields involved in morphogenesis. Calcium (Ca2+) is recognized as one such field. In this study, we demonstrate that the spatial fluctuations of Ca2+duringHydraregeneration exhibit universal characteristics. To investigate this phenomenon, we employ two distinct controls, an external electric field andheptanol, a gap junction-blocking drug. Both lead to the modulation of the Ca2+activity and a reversible halting of the regeneration process. The application of an electric field enhances Ca2+activity in theHydra's tissue and increases its spatial correlations, while the administration ofheptanolinhibits its activity and diminishes the spatial correlations. Remarkably, the statistical characteristics of Ca2+spatial fluctuations, including the coefficient of variation and skewness, manifest universal shape distributions across tissue samples and conditions. We introduce a field-theoretic model, describing fluctuations in a tilted double-well potential, which successfully captures these universal properties. Moreover, our analysis reveals that the Ca2+activity is spatially localized, and theHydra's tissue operates near the onset of bistability, where the local Ca2+activity fluctuates between low and high excited states in distinct regions. These findings highlight the prominent role of the Ca2+field inHydramorphogenesis and provide insights into the underlying mechanisms governing robust morphological transitions.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article