Retuning Mitochondrial Apoptosis/Mitophagy Balance via SIRT3-Energized and Microenvironment-Modulated Hydrogel Microspheres to Impede Osteoarthritis.

Xia, Xiaowei; Liu, Yang; Lu, Yingjie; Liu, Junlin; Deng, Yaoge; Wu, Yubin; Hou, Mingzhuang; He, Fan; Yang, Huilin; Xu, Yong; Zhang, Yijian; Zhu, Xuesong

Xia, Xiaowei; Liu, Yang; Lu, Yingjie; Liu, Junlin; Deng, Yaoge; Wu, Yubin; Hou, Mingzhuang; He, Fan; Yang, Huilin; Xu, Yong; Zhang, Yijian; Zhu, Xuesong.

Afiliação

Xia X; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Liu Y; Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215007, China.
Lu Y; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Liu J; Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215007, China.
Deng Y; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Wu Y; Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215007, China.
Hou M; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
He F; Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215007, China.
Yang H; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Xu Y; Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215007, China.
Zhang Y; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Zhu X; Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215007, China.

Adv Healthc Mater ; 12(32): e2302475, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37696643

Assuntos

Osteoartrite; Sirtuína 3; Humanos; Mitofagia/fisiologia; Sirtuína 3/metabolismo; Sirtuína 3/uso terapêutico; Hidrogéis/uso terapêutico; Microesferas; Osteoartrite/tratamento farmacológico; Condrócitos/metabolismo; Mitocôndrias; Apoptose; Ácido Hialurônico/metabolismo; Metacrilatos/química

Palavras-chave

SIRT3; mitophagy; mtApoptosis; osteoarthritis; responsive microspheres

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Sirtuína 3 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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