Direct Deoxygenation of α-Hydroxy and α,ß-Dihydroxy Ketones Using a Silyl Lithium Reagent.
J Org Chem
; 88(19): 14227-14235, 2023 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-37728533
ABSTRACT
A reliable method for the one-step direct deoxygenation of α-hydroxy ketones has been developed using a silyl lithium reagent and acetic anhydride. The method is metal-catalyst-free and does not require prefunctionalization of the hydroxy group prior to its removal. Deoxygenation of different primary, secondary, and tertiary alcohols was carried out with up to 98% isolated yield. Additionally, double deoxygenation was achieved when the present method was applied to α,ß-dihydroxy ketones to access the corresponding enones in a single step.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article