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Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
De Souza, Daniel C; Hebert, Nicolas; Esrick, Erica B; Ciuculescu, M Felicia; Archer, Natasha M; Armant, Myriam; Audureau, Étienne; Brendel, Christian; Di Caprio, Giuseppe; Galactéros, Frédéric; Liu, Donghui; McCabe, Amanda; Morris, Emily; Schonbrun, Ethan; Williams, Dillon; Wood, David K; Williams, David A; Bartolucci, Pablo; Higgins, John M.
Afiliação
  • De Souza DC; Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Hebert N; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Esrick EB; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Ciuculescu MF; French Blood Establishment (EFS), Créteil, France.
  • Archer NM; University Paris-Est-Créteil, IMRB, Laboratory of excellence LABEX, Créteil, France.
  • Armant M; Paris-East Créteil University, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Créteil, France.
  • Audureau É; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
  • Brendel C; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Di Caprio G; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Galactéros F; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Liu D; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
  • McCabe A; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Morris E; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Schonbrun E; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Williams D; INSERM U955 Team CEpiA, Paris-East Créteil University, Créteil, France.
  • Wood DK; Department of Public Health, Henri Mondor University Hospitals, APHP, Créteil, France.
  • Williams DA; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
  • Bartolucci P; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Higgins JM; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Nat Commun ; 14(1): 5850, 2023 09 20.
Article em En | MEDLINE | ID: mdl-37730674
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Falciforme / Hidroxiureia Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Falciforme / Hidroxiureia Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article