Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation.
Int J Geriatr Psychiatry
; 38(9): e6002, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37732619
ABSTRACT
BACKGROUND:
There is ample evidence in animal models that lithium increases Brain-Derived Neurotrophic Factor (BDNF) with supporting evidence in human studies. Little is known, however, about the effects of lithium on BDNF in Alzheimer's Dementia (AD). In one study of patients with Mild Cognitive Impairment, serum BDNF increased after treatment with lithium. These patients also showed mild improvement in cognitive function.OBJECTIVES:
To evaluate low-dose lithium treatment of agitation in Alzheimer's disease (AD).METHOD:
We measured levels of BDNF in patients treated with lithium prior to and after a 12-week randomized placebo-controlled trial.RESULTS:
BDNF levels did not change significantly and were not associated with improvement in overall neuropsychiatric symptoms or in cognitive function.CONCLUSIONS:
More research is needed to understand the potential effects of lithium on BDNF in AD including whether its use might be dependent on the stage of cognitive decline and dementia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
/
Disfunção Cognitiva
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article