Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers.
Medicine (Baltimore)
; 102(38): e35202, 2023 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-37747007
ABSTRACT
OBJECTIVE:
Single nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results.METHODS:
We performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC.RESULTS:
Pooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR]â =â 1.27, 95% CIâ =â 1.04-1.55, Pheterogeneityâ =â 0.18, Pâ =â .02), recessive model (ORâ =â 1.44, 95% CIâ =â 1.04-2.01, Pheterogeneityâ =â 0.19, Pâ =â .03) among Caucasians; but decreased GC risk under the allele comparison model (ORâ =â 0.89, 95% CIâ =â 0.81-0.98, Pheterogeneityâ =â 0.22, Pâ =â .02) and dominant model (ORâ =â 0.82, 95% CIâ =â 0.72-0.93, Pheterogeneityâ =â 0.15, Pâ =â .01) among Asian.CONCLUSION:
Our meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
MicroRNAs
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Neoplasias Gastrointestinais
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article