Vector-Mediated Delivery of Human Major Histocompatibility Complex-I into Hepatocytes Enables Investigation of T Cell Receptor-Redirected Hepatitis B Virus-Specific T Cells in Mice, and in Macaque Cell Cultures.

Festag, Julia; Festag, Marvin M; Asen, Theresa; Wettengel, Jochen M; Mück-Häusl, Martin A; Abdulhaqq, Shaheed; Stahl-Hennig, Christiane; Sacha, Jonah B; Burwitz, Benjamin J; Protzer, Ulrike; Wisskirchen, Karin

Festag, Julia; Festag, Marvin M; Asen, Theresa; Wettengel, Jochen M; Mück-Häusl, Martin A; Abdulhaqq, Shaheed; Stahl-Hennig, Christiane; Sacha, Jonah B; Burwitz, Benjamin J; Protzer, Ulrike; Wisskirchen, Karin.

Afiliação

Festag J; Institute of Virology, Helmholtz Zentrum München, Munich, Germany.
Festag MM; Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany.
Asen T; Institute of Virology, Helmholtz Zentrum München, Munich, Germany.
Wettengel JM; Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany.
Mück-Häusl MA; Institute of Virology, Helmholtz Zentrum München, Munich, Germany.
Abdulhaqq S; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Stahl-Hennig C; German Primate Center (DPZ), Göttingen, Germany.
Sacha JB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Burwitz BJ; Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA.
Protzer U; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Wisskirchen K; Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA.

Hum Gene Ther ; 34(23-24): 1204-1218, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37747811

Assuntos

Vírus da Hepatite B; Hepatócitos; Humanos; Camundongos; Animais; Vírus da Hepatite B/genética; Receptores de Antígenos de Linfócitos T/genética; Linfócitos T; Técnicas de Cultura de Células; Antígenos HLA-A

Palavras-chave

AAV vector; HLA-A*02; MHC-I molecule; adoptive T cell therapy; hepatitis B virus; primary macaque hepatocytes; primary mouse hepatocytes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Hepatócitos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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