Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.

Chawda, Mira M; Ross, Susan; Lau, Ching-In; Yánez, Diana C; Rowell, Jasmine; Kilbride, Peter; Crompton, Tessa

Chawda, Mira M; Ross, Susan; Lau, Ching-In; Yánez, Diana C; Rowell, Jasmine; Kilbride, Peter; Crompton, Tessa.

Afiliação

Chawda MM; UCL Great Ormond Street Institute of Child Health, London, UK.
Ross S; UCL Great Ormond Street Institute of Child Health, London, UK.
Lau CI; UCL Great Ormond Street Institute of Child Health, London, UK.
Yánez DC; UCL Great Ormond Street Institute of Child Health, London, UK.
Rowell J; UCL Great Ormond Street Institute of Child Health, London, UK.
Kilbride P; Cytiva, Danaher Corporation, Cambridge, UK.
Crompton T; UCL Great Ormond Street Institute of Child Health, London, UK.

Eur J Immunol ; 53(12): e2350546, 2023 12.

Article em En | MEDLINE | ID: mdl-37751619

ABSTRACT

ABSTRACT

Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.

Assuntos

Reconstituição Imune; Timócitos; Humanos; Animais; Camundongos; Timo; Criopreservação

Palavras-chave

Clinical immunology; Cryopreservation; Thymopoiesis; Thymus transplantation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timócitos / Reconstituição Imune Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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