Geniposide stimulates autophagy by activating the GLP-1R/AMPK/mTOR signaling in osteoarthritis chondrocytes.

Huang, Jishang; Chen, Zhixi; Wu, Zhenyu; Xie, Xunlu; Liu, Shiwei; Kong, Weihao; Zhou, Jianguo

Huang, Jishang; Chen, Zhixi; Wu, Zhenyu; Xie, Xunlu; Liu, Shiwei; Kong, Weihao; Zhou, Jianguo.

Afiliação

Huang J; Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Chen Z; College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
Wu Z; First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Xie X; Department of Pathology, Ganzhou People's Hospital, Ganzhou 341000, China.
Liu S; Department of Joint Surgery, Ganzhou People's Hospital, Ganzhou 341000, China.
Kong W; Department of Joint Surgery, Ganzhou People's Hospital, Ganzhou 341000, China.
Zhou J; Department of Joint Surgery, Ganzhou People's Hospital, Ganzhou 341000, China. Electronic address: zjg840818@163.com.

Biomed Pharmacother ; 167: 115595, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37769389

Assuntos

Autofagia; Condrócitos; Iridoides; Osteoartrite; Animais; Ratos; Proteínas Quinases Ativadas por AMP/metabolismo; Autofagia/efeitos dos fármacos; Condrócitos/efeitos dos fármacos; Osteoartrite/prevenção & controle; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Iridoides/farmacologia; Iridoides/uso terapêutico

Palavras-chave

AMPK; Autophagy; GLP-1R; Geniposide; MTOR; Osteoarthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Autofagia / Condrócitos / Iridoides Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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