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Prevalence and impact of diabetes on survival of patients with multiple myeloma in different racial groups.
Shah, Urvi A; Moshier, Erin; Derkach, Andriy; Huang, Yuanhui; Mailankody, Sham; Tan, Carlyn R; Maclachlan, Kylee; Hultcrantz, Malin; Korde, Neha; Hassoun, Hani; Thibaud, Santiago; Sanchez, Larysa; Rodriguez, Cesar; Richard, Shambavi; Richter, Joshua; Rossi, Adriana; Cho, Hearn Jay; Lesokhin, Alexander; Chari, Ajai; Usmani, Saad Z; Jagannath, Sundar; Parekh, Samir; Gallagher, Emily J.
Afiliação
  • Shah UA; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Moshier E; Department of Medicine, Weill Cornell Medical College, New York, NY.
  • Derkach A; Department of Population Health Science and Policy, Mount Sinai Health System, New York, NY.
  • Huang Y; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Mailankody S; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Tan CR; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Maclachlan K; Department of Medicine, Weill Cornell Medical College, New York, NY.
  • Hultcrantz M; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Korde N; Department of Medicine, Weill Cornell Medical College, New York, NY.
  • Hassoun H; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Thibaud S; Department of Medicine, Weill Cornell Medical College, New York, NY.
  • Sanchez L; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Rodriguez C; Department of Medicine, Weill Cornell Medical College, New York, NY.
  • Richard S; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Richter J; Department of Medicine, Weill Cornell Medical College, New York, NY.
  • Rossi A; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Cho HJ; Department of Medicine, Weill Cornell Medical College, New York, NY.
  • Lesokhin A; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Chari A; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Usmani SZ; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Jagannath S; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Parekh S; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Gallagher EJ; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
Blood Adv ; 8(1): 236-247, 2024 01 09.
Article em En | MEDLINE | ID: mdl-37772981
ABSTRACT
ABSTRACT Multiple myeloma (MM) is twice as common in Black individuals compared with in White individuals, and diabetes mellitus (DM) disproportionately affects Black patients. Although numerous studies have shown a correlation between DM and MM, this has not been studied in the context of race and in vivo mechanisms. We conducted a retrospective clinical study of 5383 patients with MM of which 15% had DM (White, 12% and Black, 25%). Multivariable Cox models showed reduced overall survival (OS) for patients with DM (hazard ratio, 1.27; 95% confidence interval, 1.11-1.47; P < .001). This appeared to be driven by a marked difference in OS between White patients with and without DM but not in Black patients. In contrast, obesity was associated with better OS in Black patients but not in White patients. To complement this analysis, we assessed MM growth in a genetically engineered immunocompromised nonobese diabetic (Rag1-/-/muscle creatinine kinase promoter expression of a human IGF1R [M] with a lysine [K] to arginine [R] point mutation) mouse model to evaluate the mechanisms linking DM and MM. MM.1S xenografts grew in more Rag1-/-/MKR mice and grew more rapidly in the Rag1-/-/MKR mice compared with in controls. Western blot analysis found that MM1.S xenografts from Rag1-/-/MKR mice had higher phosphorylated S6 ribosomal protein (Ser235/236) levels, indicating greater activation of the mammalian target of rapamycin pathway. Our study is, to our knowledge, the first to evaluate racial differences in DM prevalence and survival in MM, as well as the effect of DM on tumor growth in mouse models. Our results suggest that DM may contribute to the higher incidence of MM in Black patients; and to improve survival in MM, DM management cannot be ignored.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Mieloma Múltiplo Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Mieloma Múltiplo Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article