Development of a Highly <i>In Vivo</i> Efficacious Dual Antitumor and Antiangiogenic Organoiridium Complex as a Potential Anti-Lung Cancer Agent.

Gadre, Shubhankar; M, Manikandan; Chakraborty, Gourav; Rayrikar, Amey; Paul, Subhadeep; Patra, Chinmoy; Patra, Malay

Development of a Highly In Vivo Efficacious Dual Antitumor and Antiangiogenic Organoiridium Complex as a Potential Anti-Lung Cancer Agent.

Gadre, Shubhankar; M, Manikandan; Chakraborty, Gourav; Rayrikar, Amey; Paul, Subhadeep; Patra, Chinmoy; Patra, Malay.

Afiliação

Gadre S; Medicinal Chemistry and Cell Biology Laboratory, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, Maharashtra 400005, India.
M M; Medicinal Chemistry and Cell Biology Laboratory, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, Maharashtra 400005, India.
Chakraborty G; Department of Developmental Biology, Agharkar Research Institute, G G Agarkar Road, Pune, Maharashtra 411004, India.
Rayrikar A; Department of Developmental Biology, Agharkar Research Institute, G G Agarkar Road, Pune, Maharashtra 411004, India.
Paul S; Medicinal Chemistry and Cell Biology Laboratory, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, Maharashtra 400005, India.
Patra C; Department of Developmental Biology, Agharkar Research Institute, G G Agarkar Road, Pune, Maharashtra 411004, India.
Patra M; Medicinal Chemistry and Cell Biology Laboratory, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, Maharashtra 400005, India.

J Med Chem ; 66(19): 13481-13500, 2023 10 12.

Article em En | MEDLINE | ID: mdl-37784224

Assuntos

Antineoplásicos; Complexos de Coordenação; Neoplasias Pulmonares; Humanos; Animais; Camundongos; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Antineoplásicos/química; Peixe-Zebra; Cisplatino; Neoplasias Pulmonares/tratamento farmacológico; Complexos de Coordenação/farmacologia; Complexos de Coordenação/uso terapêutico; Complexos de Coordenação/química; Irídio/química; Linhagem Celular Tumoral

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexos de Coordenação / Neoplasias Pulmonares / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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