Extragenic suppression of an HSV-1 UL34 nuclear egress mutant reveals role for pUS9 as an inhibitor of epithelial cell-to-cell spread.
J Virol
; 97(10): e0083623, 2023 10 31.
Article
em En
| MEDLINE
| ID: mdl-37787529
ABSTRACT
IMPORTANCE Herpesviruses are able to disseminate in infected hosts despite development of a strong immune response. Their ability to do this relies on a specialized process called cell-to-cell spread in which newly assembled virus particles are trafficked to plasma membrane surfaces that abut adjacent uninfected cells. The mechanism of cell-to-cell spread is obscure, and little is known about whether or how it is regulated in different cells. We show here that a viral protein with a well-characterized role in promoting spread from neurons has an opposite, inhibitory role in other cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
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Núcleo Celular
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Herpesvirus Humano 1
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Estruturas da Membrana Celular
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Peptídeos e Proteínas de Sinalização Intracelular
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Células Epiteliais
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Liberação de Vírus
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Lipoproteínas
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Mutação
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article