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Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis.
Bartels, Yvonne L; van Lent, Peter L E M; van der Kraan, Peter M; Blom, Arjen B; Bonger, Kimberly M; van den Bosch, Martijn H J.
Afiliação
  • Bartels YL; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van Lent PLEM; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van der Kraan PM; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Blom AB; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Bonger KM; Synthetic Organic Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
  • van den Bosch MHJ; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Rheumatology (Oxford) ; 63(3): 608-618, 2024 Mar 01.
Article em En | MEDLINE | ID: mdl-37788083
Local and systemic low-grade inflammation, mainly involving the innate immune system, plays an important role in the development of OA. A receptor playing a key role in initiation of this inflammation is the pattern-recognition receptor Toll-like receptor 4 (TLR4). In the joint, various ligands for TLR4, many of which are damage-associated molecular patterns (DAMPs), are present that can activate TLR4 signalling. This leads to the production of pro-inflammatory and catabolic mediators that cause joint damage. In this narrative review, we will first discuss the involvement of TLR4 ligands and signalling in OA. Furthermore, we will provide an overview of methods for inhibit, TLR4 signalling by RNA interference, neutralizing anti-TLR4 antibodies, small molecules and inhibitors targeting the TLR4 co-receptor MD2. Finally, we will focus on possible applications and challenges of these strategies in the dampening of inflammation in OA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Receptor 4 Toll-Like Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Receptor 4 Toll-Like Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article