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Exploration of the novel fluoroquinolones with high inhibitory effect against quinolone-resistant DNA gyrase of Salmonella Typhimurium.
Toyting, Jirachaya; Miura, Nami; Utrarachkij, Fuangfa; Tanomsridachchai, Wimonrat; Belotindos, Lawrence P; Suwanthada, Pondpan; Kapalamula, Thoko Flav; Kongsoi, Siriporn; Koide, Kentaro; Kim, Hyun; Thapa, Jeewan; Nakajima, Chie; Suzuki, Yasuhiko.
Afiliação
  • Toyting J; Division of Bioresources, Hokkaido University International Institute for Zoonosis Control , Sapporo, Japan.
  • Miura N; Division of Bioresources, Hokkaido University International Institute for Zoonosis Control , Sapporo, Japan.
  • Utrarachkij F; Department of Microbiology, Faculty of Public Health, Mahidol University , Bangkok, Thailand.
  • Tanomsridachchai W; Division of Bioresources, Hokkaido University International Institute for Zoonosis Control , Sapporo, Japan.
  • Belotindos LP; Biosafety and Environment Section, Research and Development Division, Philippine Carabao Center National Headquarters and Gene Pool Science City of Munoz , Munoz, Nueva Ecija, Philippines.
  • Suwanthada P; Division of Bioresources, Hokkaido University International Institute for Zoonosis Control , Sapporo, Japan.
  • Kapalamula TF; Division of Bioresources, Hokkaido University International Institute for Zoonosis Control , Sapporo, Japan.
  • Kongsoi S; Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University , Nakhon Pathom, Thailand.
  • Koide K; Department of Bacteriology II, National Institute of Infectious Diseases , Tokyo, Japan.
  • Kim H; Department of Bacteriology II, National Institute of Infectious Diseases , Tokyo, Japan.
  • Thapa J; Division of Bioresources, Hokkaido University International Institute for Zoonosis Control , Sapporo, Japan.
  • Nakajima C; Division of Bioresources, Hokkaido University International Institute for Zoonosis Control , Sapporo, Japan.
  • Suzuki Y; Hokkaido University Institute for Vaccine Research & Development, Hokkaido University , Sapporo, Japan.
Microbiol Spectr ; 11(6): e0133023, 2023 Dec 12.
Article em En | MEDLINE | ID: mdl-37795999
ABSTRACT
IMPORTANCE Quinolone-resistant nontyphoidal Salmonella is a pressing public health concern, demanding the exploration of novel treatments. In this study, we focused on two innovative synthetic fluoroquinolones, WQ-3034 and WQ-3154. Our findings revealed that these new compounds demonstrate potent inhibitory effects, even against mutant strains that cause resistance to existing quinolones. Hence, WQ-3034 and WQ-3154 could potentially be effective therapeutic agents against quinolone-resistant Salmonella Typhimurium. Furthermore, the data obtained in this study will be baseline information for antimicrobial drug development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas Idioma: En Ano de publicação: 2023 Tipo de documento: Article