Carotid intima layer thickness but not intima-media thickness is related to coronary artery calcification in type 2 diabetes individuals: Results from the Brazilian diabetes study.
Nutr Metab Cardiovasc Dis
; 33(12): 2384-2388, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37798228
ABSTRACT
BACKGROUND AND AIMS:
Carotid intima-media thickness (cIMT) is inconsistent in predicting cardiovascular risk. This may stem from the variability of the media thickness (cM) outweighing the intimal thickness (cIT) as the sign of atherosclerosis. Thus, we evaluated in type 2 diabetes (T2D) individuals, the association between carotid measures and coronary artery calcification (CAC). METHODS ANDRESULTS:
Association between the presence of CAC and cIT, cM, and cIMT were examined on 224 individuals. Logistic binary regression was used to assess CAC predictors. The Akaike information criterion (AIC) and log-likelihood test (LLT) were used to assess differences among univariate models. The cIT (0.335 mm vs 0.363 mm; p = 0.001) and cIMT (0.715 vs 0.730; p = 0.019), but not cM (0.386 mm vs 0,393 mm; p = 0.089) were higher among individuals with CAC. In unadjusted analysis, cIT (273;-134; p = 0.001) showed greater relationship with CAC, when compared to cIMT (279;-137; p = 0.022) and cM (281;-139; p = 0.112) based on the AIC and LLT, respectively. In multivariate logistic regression, CAC was related to carotid plaque (OR) 1.91, 95% confidence interval (CI)1.08, 3.38; p = 0.027), and high-cIT (OR 2.70, 95%CI1.51, 4.84; p = 0.001), but not to high-cIMT (OR1.70, 95%CI0.96, 3.00; p = 0.067) nor high-cM (OR1.33, 95%CI0.76, 2.34; p = 0.322).CONCLUSION:
In T2D individuals, cIT is a better predictor of CAC than cIMT; cM is not associated with CAC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Doenças das Artérias Carótidas
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article