Hippocampal neurons code individual episodic memories in humans.
Nat Hum Behav
; 7(11): 1968-1979, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37798368
ABSTRACT
The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. Here we provide evidence for the latter hypothesis. Using single-neuron recordings from a total of 30 participants, we show that individual neurons, which we term episode-specific neurons, code discrete episodic memories using either a rate code or a temporal firing code. These neurons were observed exclusively in the hippocampus. Importantly, these episode-specific neurons do not reflect the coding of a particular element in the episode (that is, concept or time). Instead, they code for the conjunction of the different elements that make up the episode.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Memória Episódica
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article