FZD7: A potential biomarker for endometriosis.
Medicine (Baltimore)
; 102(40): e35406, 2023 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-37800830
ABSTRACT
BACKGROUND:
Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown.METHODS:
In this study, we aimed to investigate whether Frizzled-7 (FZD7) would effectively promote the development of endometriosis. The microarray-based data analysis was performed to screen endometriosis-related differentially expressed genes. This process uncovered specific hub genes, and the nexus of vital genes and ferroptosis-related genes were pinpointed. Then, we collected human endometrial and endometriotic tissues from patients with endometriosis of the ovary (nâ =â 39) and control patients without endometriosis (nâ =â 10, who underwent hysterectomy for uterine fibroids) to compare the expression of FZD7.RESULTS:
These findings indicated that the expression of FZD7 was high compared with normal endometrium, and FZD7 may promote the progression of endometriosis.CONCLUSION:
FZD7 may serve as a potential therapeutic target for endometriosis treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endometriose
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article