Photomodulation of the ASIC1a acidic pocket destabilizes the open state.

Rook, Matthew L; McCullock, Tyler W; Couch, Tyler; Lueck, John D; MacLean, David M

Rook, Matthew L; McCullock, Tyler W; Couch, Tyler; Lueck, John D; MacLean, David M.

Afiliação

Rook ML; Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
McCullock TW; Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Couch T; Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Lueck JD; Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
MacLean DM; Deparment of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.

Protein Sci ; 32(11): e4800, 2023 11.

Article em En | MEDLINE | ID: mdl-37805833

Assuntos

Canais Iônicos Sensíveis a Ácido; Canais Iônicos Sensíveis a Ácido/genética; Canais Iônicos Sensíveis a Ácido/química; Canais Iônicos Sensíveis a Ácido/metabolismo; Conformação Molecular; Concentração de Íons de Hidrogênio

Palavras-chave

ASICs; acid-sensing ion channels; acidic pocket; gating; genetic code expansion; photomodulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais Iônicos Sensíveis a Ácido Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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