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Development of a novel serological assay for the detection of mpox infection in vaccinated populations.
Yates, Jennifer L; Hunt, Danielle T; Kulas, Karen E; Chave, Karen J; Styer, Linda; Chakravarthi, Sandhya T; Cai, Gianna Y; Bermúdez-González, Maria C; Kleiner, Giulio; Altman, Deena; Srivastava, Komal; Simon, Viviana; Feihel, Dennis; McGowan, Joseph; Hogrefe, Wayne; Noone, Philip; Egan, Christina; Slifka, Mark K; Lee, William T.
Afiliação
  • Yates JL; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  • Hunt DT; Department of Biomedical Sciences, The School of Public Heath, The University at Albany, Albany, New York, USA.
  • Kulas KE; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  • Chave KJ; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  • Styer L; Scientific Cores, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  • Chakravarthi ST; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  • Cai GY; Department of Biomedical Sciences, The School of Public Heath, The University at Albany, Albany, New York, USA.
  • Bermúdez-González MC; Scientific Cores, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
  • Kleiner G; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Altman D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Srivastava K; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Simon V; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Feihel D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • McGowan J; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Hogrefe W; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Noone P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Egan C; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Slifka MK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Lee WT; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, USA.
J Med Virol ; 95(10): e29134, 2023 10.
Article em En | MEDLINE | ID: mdl-37805977
ABSTRACT
In 2022 the World Health Organization declared a Public Health Emergency for an outbreak of mpox, the zoonotic Orthopoxvirus (OPV) affecting at least 104 nonendemic locations worldwide. Serologic detection of mpox infection is problematic, however, due to considerable antigenic and serologic cross-reactivity among OPVs and smallpox-vaccinated individuals. In this report, we developed a high-throughput multiplex microsphere immunoassay using a combination of mpox-specific peptides and cross-reactive OPV proteins that results in the specific serologic detection of mpox infection with 93% sensitivity and 98% specificity. The New York State Non-Vaccinia Orthopoxvirus Microsphere Immunoassay is an important tool to detect subclinical mpox infection and understand the extent of mpox spread in the community through retrospective analysis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthopoxvirus / Mpox Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthopoxvirus / Mpox Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article