Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion.

Xie, Dina; Guo, Hanliang; Li, Mingbiao; Jia, Liqun; Zhang, Hao; Liang, Degang; Wu, Naishi; Yang, Zequan; Tian, Yikui

Xie, Dina; Guo, Hanliang; Li, Mingbiao; Jia, Liqun; Zhang, Hao; Liang, Degang; Wu, Naishi; Yang, Zequan; Tian, Yikui.

Afiliação

Xie D; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Guo H; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Li M; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Jia L; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Zhang H; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Liang D; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Wu N; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Yang Z; Department of Surgery, University of Virginia, Charlottesville, VA, USA.
Tian Y; Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China. ykt@tmu.edu.cn.

Basic Res Cardiol ; 118(1): 44, 2023 10 09.

Article em En | MEDLINE | ID: mdl-37814087

Assuntos

Ácidos Nucleicos Livres; Infarto do Miocárdio; Traumatismo por Reperfusão Miocárdica; Traumatismo por Reperfusão; Humanos; Camundongos; Animais; Traumatismo por Reperfusão Miocárdica/metabolismo; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Monócitos/metabolismo; Receptor Toll-Like 9; Baço/metabolismo; Infarto do Miocárdio/metabolismo

Palavras-chave

Inflammatory response; Myocardial ischemia/reperfusion injury; NLRP3; Spleen; cfDNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Traumatismo por Reperfusão / Ácidos Nucleicos Livres / Infarto do Miocárdio Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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