Upregulation by duloxetine of the transforming growth factor-&#945;-induced migration of hepatocellular carcinoma cells via enhancement of the c-Jun N-terminal kinase activity.

Matsushima-Nishiwaki, Rie; Kamoi, Shota; Kozawa, Osamu

Upregulation by duloxetine of the transforming growth factor-α-induced migration of hepatocellular carcinoma cells via enhancement of the c-Jun N-terminal kinase activity.

Matsushima-Nishiwaki, Rie; Kamoi, Shota; Kozawa, Osamu.

Afiliação

Matsushima-Nishiwaki R; Department of Pharmacology, Graduate School of Medicine, Gifu University, Gifu, Gifu Prefecture, Japan.
Kamoi S; Department of Pharmacology, Graduate School of Medicine, Gifu University, Gifu, Gifu Prefecture, Japan.
Kozawa O; Department of Pharmacology, Graduate School of Medicine, Gifu University, Gifu, Gifu Prefecture, Japan.

Cell Biochem Funct ; 41(7): 814-822, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37814477

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Carcinoma Hepatocelular/patologia; Cloridrato de Duloxetina/farmacologia; Fluvoxamina/farmacologia; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Neoplasias Hepáticas/patologia; Norepinefrina; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Fosforilação; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serotonina/metabolismo; Sertralina/farmacologia; Fator de Crescimento Transformador alfa/farmacologia; Fator de Crescimento Transformador alfa/metabolismo; Regulação para Cima

Palavras-chave

HCC; JNK; TGF-α; duloxetine; migration; serotonin transporter

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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