[New and Established Multimodal Therapeutic Strategies in Advanced Rectal Cancer].
Praxis (Bern 1994)
; 112(11): 539-544, 2023 Sep.
Article
em De
| MEDLINE
| ID: mdl-37823809
ABSTRACT
INTRODUCTION:
Locally advanced rectal cancer has a high risk of local recurrence which can be reduced by multimodal therapy. Neoadjuvant radiotherapy or radiochemotherapy has been established. Nevertheless, this has not proved to improve overall survival. The benefit of adjuvant chemotherapy after neoadjuvant radiotherapy or radiochemotherapy remains unclear. Current studies are investigating total neoadjuvant therapy with different sequences of radiotherapy and chemotherapy followed by rectal resection. This procedure shows high pathologic complete remissions up to 28 % as well as an improvement in disease-free and metastasis-free survival. Under study conditions, in case of clinical complete remission, watchful waiting with close follow-up and surgery can be considered only in case of local tumor recurrence.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
Limite:
Humans
Idioma:
De
Ano de publicação:
2023
Tipo de documento:
Article