Conjugation with glucagon like peptide-1 enables targeted protein degradation.

Zhu, Liquan; Zhou, Yiyu; Zhang, Bei; Luo, Yin; Fang, Chen; Yan, Xiaoqiao; Cai, Yefeng; Jiang, Linye; Ge, Jingyan

Zhu, Liquan; Zhou, Yiyu; Zhang, Bei; Luo, Yin; Fang, Chen; Yan, Xiaoqiao; Cai, Yefeng; Jiang, Linye; Ge, Jingyan.

Afiliação

Zhu L; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Zhou Y; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Zhang B; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Luo Y; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Fang C; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Yan X; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Cai Y; Department of Thyroid Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Jiang L; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Ge J; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: gejy@zjut.edu.cn.

Bioorg Chem ; 141: 106908, 2023 12.

Article em En | MEDLINE | ID: mdl-37827016

Assuntos

Peptídeo 1 Semelhante ao Glucagon; Proteólise

Palavras-chave

EGFR; GLP-1; LYTAC; PD-L1; Protein degradation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo 1 Semelhante ao Glucagon Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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