Proteasome activity is required for reovirus entry into cells.
J Virol
; 97(10): e0134823, 2023 10 31.
Article
em En
| MEDLINE
| ID: mdl-37830819
ABSTRACT
IMPORTANCE Due to their limited genetic capacity, viruses are reliant on multiple host systems to replicate successfully. Mammalian orthoreovirus (reovirus) is commonly used as a model system for understanding host-virus interactions. In this study, we identify that the proteasome system, which is critical for cellular protein turnover, affects reovirus entry. Inhibition of the proteasome using a chemical inhibitor blocks reovirus uncoating. Blocking these events reduces subsequent replication of the virus. This work identifies that additional host factors control reovirus entry.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reoviridae
/
Complexo de Endopeptidases do Proteassoma
/
Internalização do Vírus
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article