Diagnostic performance of microRNA-29a in active pulmonary tuberculosis: a systematic review and meta-analysis.
Clinics (Sao Paulo)
; 78: 100290, 2023.
Article
em En
| MEDLINE
| ID: mdl-37837919
ABSTRACT
BACKGROUND:
In recent years, more and more studies have shown that microRNA-29a (miRNA-29a) can be used as a potential biomarker for active tuberculosis, but the results of these studies are not consistent.OBJECTIVE:
To comprehensively evaluate the value of miRNA-29a in the diagnosis of active tuberculosis by meta-analysis.METHODS:
The databases of CNKI, WanFang, PubMed, The Cochrane Library, Web of Science and EMBASE were searched for relevant studies. Studies were screened strictly according to inclusion and exclusion criteria. QUADAS-2 scale was used to evaluate the quality of the included studies. Data were extracted and analyzed by Meta-DiSc 1.4 and Stata 16.0 software.RESULTS:
13 articles were included, including a total of 1598 subjects, including 872 active tuberculosis patients and 726 controls. The combined sensitivity and specificity of miRNA-29a in the diagnosis of active tuberculosis were 78 % and 76 %, respectively, and the area under the overall summary receiver operating characteristic curve was 0.8564.CONCLUSION:
miRNA-29a can be used as a biomarker for the diagnosis of active tuberculosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Tuberculose Pulmonar
/
MicroRNAs
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article