Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer and overcoming drug resistance.

Hsieh, Yao-Yu; Du, Jia-Ling; Yang, Pei-Ming

Hsieh, Yao-Yu; Du, Jia-Ling; Yang, Pei-Ming.

Afiliação

Hsieh YY; Division of Hematology and Oncology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.
Du JL; Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yang PM; Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan.

Mol Oncol ; 18(2): 386-414, 2024 Feb.

Article em En | MEDLINE | ID: mdl-37842807

Assuntos

Antineoplásicos; Neoplasias Colorretais; Camundongos; Animais; Humanos; Reposicionamento de Medicamentos; Linhagem Celular Tumoral; Camundongos Nus; Resistencia a Medicamentos Antineoplásicos; Microtúbulos/metabolismo; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo

Palavras-chave

colorectal cancer; connectivity map; drug repositioning; drug resistance; microtubule-targeting agent; polypharmacology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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