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The role of MicroRNA as a potential diagnostic and prognostic biomarker for cerebral aneurysms.
Al-Jehani, Hosam M; Turkistani, Alaa N; Alrayes, Majd M; AlHamid, May A; AlShamikh, Arwa S; Al Sadah, Zhra M; Alabbas, Faisal M; Cyrus, Cyril; Al-Ali, Amein K.
Afiliação
  • Al-Jehani HM; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • Turkistani AN; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • Alrayes MM; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • AlHamid MA; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • AlShamikh AS; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • Al Sadah ZM; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • Alabbas FM; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • Cyrus C; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
  • Al-Ali AK; From the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdu
Neurosciences (Riyadh) ; 28(4): 250-257, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37844954
ABSTRACT

OBJECTIVES:

To identify the dysregulated functional miRNAs, miRNA-16, miRNA-143, and miRNA-200 as potential biomarkers of cerebral aneurysms(CAs) to aid in diagnosis and prognosis.

METHODS:

This is a prospective case-control study conducted among patients with CA. All patients' computed tomography angiography (CTA) and interventional angiogram were assessed and studied. The miRNAs were isolated and quantified from peripheral blood samples and the expression profiling was done using TaqMan chemistry on Real-Time PCR.

RESULTS:

A total of 37 samples were included. Three cases had double aneurysms and 10 cases presented with aneurysmal rupture. miRNA-16, miRNA-143, and miRNA-200 were upregulated with an absolute fold-change of >8 in the CA group in comparison to controls (p<0.05). miRNA-200 showed double expression in patients with single aneurysm. A statically significant increase was observed in the expression of miRNA-143 in patients who had an aneurysmal rupture with p<0.05. Diabetic patients showed an obvious increase in miRNA-200 (13.03 folds) and miRNA-16 (26.82 folds) expression. Also, there was a notable elevation in miRNA-16, miRNA-143, and miRNA-200 in patients who had hypertension in comparison to those who did not.

CONCLUSION:

miRNA-16, miRNA-143, and miRNA-200 showed statically significant higher expression among cases with cerebral aneurysms in comparison to controls. Thus, these preliminary results of miRNAs biomarkers are promising future tool to be used for aneurysmal screening.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aneurisma Intracraniano / MicroRNAs Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aneurisma Intracraniano / MicroRNAs Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article