Addressing Motor Dysfunction by a Selective α6-Containing Nicotinic Receptor Antagonist.
J Med Chem
; 66(21): 14494-14496, 2023 11 09.
Article
em En
| MEDLINE
| ID: mdl-37852222
ABSTRACT
In the striatum, presynaptic α6-containig nicotinic receptors are crucially involved in the modulation of dopamine release. CVN417, a novel selective antagonist at this receptor subtype, attenuates motor dysfunction in a Parkinson's disease-relevant animal model, suggesting, for this pathology, a therapeutic strategy that could greatly profit from the restricted localization of α6* nicotinic receptors in the brain.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Receptores Nicotínicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article