Sustainable Organic Photocatalysis for Site-Selective Hydrazocoupling of Electron-Rich Arenes.
Org Lett
; 25(42): 7733-7738, 2023 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-37853522
ABSTRACT
An efficient photocatalytic para- and ortho-selective amination and aminative dearomatization of phenols, naphthols, and anilines with azodicarboxylates was developed using riboflavin tetraacetate (RFTA) as an organic photocatalyst. The site selectivity was controlled using tetrabutylammonium bromide (TBAB), which also acts as a phase transfer catalyst. The reaction conditions are simple and mild, giving high regioselectivity with good to excellent yields. A broad substrate scope and nice functional group tolerance with scalability and post-functionalization make this protocol both useful and regioselective.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article