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Biomarkers of alcohol abuse potentially predict delirium, delirium duration and mortality in critically ill patients.
Schreiber, Nikolaus; Reisinger, Alexander C; Hatzl, Stefan; Schneider, Nikolaus; Scholz, Laura; Herrmann, Markus; Kolland, Michael; Schuller, Max; Kirsch, Alexander H; Eller, Kathrin; Kink, Christiane; Fandler-Höfler, Simon; Rosenkranz, Alexander R; Hackl, Gerald; Eller, Philipp.
Afiliação
  • Schreiber N; Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
  • Reisinger AC; Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
  • Hatzl S; Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
  • Schneider N; Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
  • Scholz L; Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
  • Herrmann M; Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
  • Kolland M; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
  • Schuller M; Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
  • Kirsch AH; Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
  • Eller K; Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
  • Kink C; Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
  • Fandler-Höfler S; Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
  • Rosenkranz AR; Department of Neurology, Medical University Graz, Graz, Austria.
  • Hackl G; Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
  • Eller P; Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
iScience ; 26(10): 108044, 2023 Oct 20.
Article em En | MEDLINE | ID: mdl-37854697
ABSTRACT
Carbohydrate-deficient transferrin (CDT) and the γ-glutamyltransferase-CDT derived Anttila-Index are established biomarkers for sustained heavy alcohol consumption and their potential role to predict delirium and mortality in critically ill patients is not clear. In our prospective observational study, we included 343 consecutive patients admitted to our ICU, assessed the occurrence of delirium and investigated its association with biomarkers of alcohol abuse measured on the day of ICU admission. 35% of patients developed delirium during ICU stay. We found significantly higher CDT levels (p = 0.011) and Anttila-Index (p = 0.001) in patients with delirium. CDT above 1.7% (OR 2.06), CDT per percent increase (OR 1.26, AUROC 0.75), and Anttila-Index per unit increase (OR 1.28, AUROC 0.74) were associated with delirium development in adjusted regression models. Anttila-Index and CDT also correlated with delirium duration exceeding 5 days. Additionally, Anttila-Index above 4, Anttila-Index per unit increase, and CDT per percent increase were independently associated with hospital mortality.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article