The Nonclinical Assessment of Trans-1,3,3,3-tetrafluoropropene (HFO-1234ze (E)), a Near Zero Global Warming Potential Propellant for Use in Metered Dose Inhalation Products.

Giffen, Paul S; Kilgour, Joanne D; Jacobsen, Matthew; Thacker, Karen; Holmberg, Ann A

Giffen, Paul S; Kilgour, Joanne D; Jacobsen, Matthew; Thacker, Karen; Holmberg, Ann A.

Afiliação

Giffen PS; Department of Respiratory & Immunology Toxicology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Kilgour JD; ApconiX, Macclesfield, UK.
Jacobsen M; Department of Pathology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Thacker K; Department of Regulatory Toxicology and Safety Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Holmberg AA; Department of Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Int J Toxicol ; 43(1): 4-18, 2024.

Article em En | MEDLINE | ID: mdl-37860941

Assuntos

Fluorocarbonos; Aquecimento Global; Animais; Cães; Feminino; Camundongos; Ratos; Administração por Inalação; Lactação

Palavras-chave

HFO-1234ze (E); inhalation; metered dose inhaler; nonclinical; safety; toxicokinetics; toxicology; trans-1,3,3,3-tetrafluoropropene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aquecimento Global / Fluorocarbonos Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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